影片讲述了拳手马蒂（帕迪·康斯戴恩饰）是一名世界中量级拳击冠军，跟妻子艾玛（朱迪·惠特克饰）有一个漂亮的女儿米娅，在他的职业生涯即将结束之际的最后一场拳击比赛中，马蒂遇到了一个强有力的年轻对手——傲慢、古怪又有争议的安德鲁，安德鲁一直扬言要得冠军，这场比赛彻底改变了马蒂 的人生。比赛结束后，马蒂卫冕成功，但是脑部却受到严重的撞击，他的生活、婚姻和未来都发生了巨大的变化。

　　Hayley Udall tries to make ends meet for herself and her 14 year-old daughter while providing alimony for a horrible ex-husband. She wishes her problems with her ex could go away, and upon venting her frustrations one night, finds herself tangled up in a pact with two people (Melanie and Kevin) to "eliminate" each other's problems. It seemed innocent wishful thinking before, but as people end up dead-including Hayley's ex-husband-Hayley is trapped to fulfill the pact or risk taking the fall for murder. She tries to clear her name but the police (led by Detective Marks) is eyeing her for her ex-husband's death as well as others. Then Melanie abducts Hayley's daughter as leverage for Hayley to follow through and kill one last person. With Detective Marks trying to find the truth, Hayley must hurry to save her daughter and find a way to avoid murder.

　　While a virus that causes the dead to reanimate brings the world to its knees, the scientist responsible entrusts his cataclysmic findings to Katya Nevin, a troubled ex-war correspondent turned anchor-woman at W.W News. While she and the rest of her crew witness the collapse of society via video feeds from around the globe, a deadly special agent climbs the building floor by floor, his only goal to ensure her silence. Armed only with information and an indomitable will to live, Katya must overcome her crippling anxiety and learn to lead in order to make it out of the studio and into a terrifying new world where only the dead survive.

　　斯宾塞、“冰箱”弗里奇、贝瑟尼和玛莎是某高中的问题学生，这一日他们因不同的错误而被留校劳动。在一间堆满陈旧废弃物的储藏室内，斯宾塞发现一台年代久远的游戏机。四人原本想放松一下，谁知却被吸进了游戏机中。在凶险的尤曼吉热带丛林里，少男少女分别变成了勇石博士（道恩·强森 Dwayne Johnson 饰）、毛子·芬巴（凯文·哈特 Kevin Hart 饰）、奥伯伦教授（杰克·布莱克 Jack Black 饰）和铁拳露比（凯伦·吉兰 Karen Gillan 饰），他们必须遵照游戏规则，突破邪恶博士的阻挠，将宝石放回原处，恢复尤曼吉的和平，而这也是他们重返现实世界的唯一途径。
　　毒蛇、猛兽以及纠缠不休的暴徒，为四个玩家带来了永生难忘的冒险体验……